Jim Van Os. Enda M Byrne. And how do you know? If the negative association between RA and SCZ reflects genetic factors, then it may be driven predominantly by non-HLA genetic factors that are related to immune activation rather than antigen recognition.
Arthritis Rheum ; 43 : 30 — Given there was no evidence of contribution to risk of common variants for this sample, detection of a genetic relationship between these cases and SZ was not possible. We undertook genomic partitioning analyses in which multiple additive genetic random effects terms were considered in the linear mixed model, 4549 with multiple GRM each constructed from SNPs grouped by a functional annotation.
Our analyses led us to hypothesize a gene-environment interaction for SZ in the form of immune challenge. SNP heritabilities are presented on the liability scale. Immune dysregulation and self-reactivity in schizophrenia: do some cases of schizophrenia have an autoimmune basis?
Marieke JH Coenen. Supplementary Data - zip file. Impact of diagnostic misclassification on estimation of genetic correlations using genome-wide genotypes.
Receive exclusive offers and updates from Oxford Academic. Oxford Academic. S Louis Bridges, Jr. At issue: schizophrenia and rheumatoid arthritis: the negative association revisited.